Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat

Verena Labi, Siying Peng, Filippos Klironomos, Mathias Munschauer, Nicolai Kastelic, Tirtha Chakraborty, Katia Schoeler, Emmanuel Derudder, Manuela Martella, Guido Mastrobuoni, Luis R. Hernandez-Miranda, Ines Lahmann, Christine Kocks, Carmen Birchmeier, Stefan Kempa, Leticia Quintanilla-Martinez de Fend, Markus Landthaler, Nikolaus Rajewsky, Klaus Rajewsky

Genes & Development, vol. 33, 2019 Nov 1, pp. 1673-1687

Addiction of B Cell Lymphomas to microRNA-17-92 Is Mediated By a Single Target Gene

Katia Schoeler, Teresa Mittermeier, Andreas Villunger, Klaus Rajewsky, Verena Labi

Blood, vol. 134, 2019 Oct 13, pp. 1258-1258

Transient apoptosis inhibition in donor stem cells improves hematopoietic stem cell transplantation.

Matthias Kollek, Gesina Voigt, Christian Molnar, Fabronia Murad, Daniela Bertele, Christopher Felix Krombholz, Sheila Bohler, Verena Labi, Stefan Schiller, Mirjam Kunze, Stephan Geley, Charlotte M. Niemeyer, Ana Garcia-Saez, Miriam Erlacher

Journal of Experimental Medicine, vol. 214(10), 2017 Sep 2, pp. 2967-2983

Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells

Emmanuel Derudder, Sebastian Herzog, Verena Labi, Tomoharu Yasuda, Karl Köchert, Martin Janz, Andreas Villunger, Marc Schmidt-Supprian, Klaus Rajewsky

Proceedings of the National Academy of Sciences of the United States of America, vol. 113(18), 2016 Apr 3, pp. 5065-5070

Tissue-specific DNA demethylation is required for proper B-cell differentiation and function.

Shari Orlanski, Verena Labi, Yitzhak Reizel, Adam Spiro, Michal Lichtenstein, Rena Levin-Klein, Sergei B. Koralov, Yael Skversky, Klaus Rajewsky, Howard Cedar, Yehudit Bergman

Proceedings of the National Academy of Sciences of the United States of America, vol. 113(18), 2016 Apr 3, pp. 5018-5023

How cell death shapes cancer

V Labi, M Erlacher

Cell Death and Disease, vol. 6(3), 2015 Feb 5

Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf.

Verena Labi, Claudia Woess, Selma Tuzlak, Miriam Erlacher, Philippe Bouillet, Andreas Strasser, Alexandar Tzankov, Andreas Villunger

Blood, vol. 123(17), 2014 Mar 24, pp. 2652-2662

Minor cell death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf

F Baumgartner, C Woess, V Pedit, A Tzankov, V Labi, A Villunger

Oncogene, vol. 32(5), 2013 31, pp. 621-630

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

Espen Melum, Andre Franke, Christoph Schramm, Tobias J Weismüller, Daniel Nils Gotthardt, Felix A Offner, Brian D Juran, Jon K Laerdahl, Verena Labi, Einar Björnsson, Rinse K Weersma, Liesbet Henckaerts, Andreas Teufel, Christian Rust, Eva Ellinghaus, Tobias Balschun, Kirsten Muri Boberg, David Ellinghaus, Annika Bergquist, Peter Sauer, Euijung Ryu, Johannes Roksund Hov, Jochen Wedemeyer, Björn Lindkvist, Michael Wittig, Robert J Porte, Kristian Holm, Christian Gieger, H-Erich Wichmann, Pieter Stokkers, Cyriel Y Ponsioen, Heiko Runz, Adolf Stiehl, Cisca Wijmenga, Martina Sterneck, Severine Vermeire, Ulrich Beuers, Andreas Villunger, Erik Schrumpf, Konstantinos N Lazaridis, Michael P Manns, Stefan Schreiber, Tom H Karlsen

Nature Genetics, vol. 43(1), 2011 1, pp. 17-19

AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.

Antonio F. Santidrián, Diana M. González-Gironès, Daniel Iglesias-Serret, Llorenç Coll-Mulet, Ana M. Cosialls, Mercè de Frias, Clara Campàs, Eva González-Barca, Esther Alonso, Verena Labi, Benoit Viollet, Adalberto Benito, Gabriel Pons, Andreas Villunger, Joan Gil

Blood, vol. 116(16), 2010 Sep 21, pp. 3023-3032

Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation

Verena Labi, Miriam Erlacher, Gerhard Krumschnabel, Claudia Manzl, Alexandar Tzankov, Josephina Pinon, Alexander Egle, Andreas Villunger

Genes & Development, vol. 24(15), 2010 Jul 1, pp. 1602-1607

Caspase-2 activation in the absence of PIDDosome formation.

Claudia Manzl, Gerhard Krumschnabel, Florian Bock, Benedicte Sohm, Verena Labi, Florian Baumgartner, Emmanuelle Logette, Jürg Tschopp, Andreas Villunger

Journal of Cell Biology, vol. 185(2), 2009 Mar 20, pp. 291-303

Bim and Bmf in tissue homeostasis and malignant disease.

J D Piñon, V Labi, A Egle, A Villunger

Oncogene, vol. 27(1), 2008 Nov 1

The Nuclear Orphan Receptor NR2F6 Suppresses Lymphocyte Activation and T Helper 17-Dependent Autoimmunity

Natascha Hermann-Kleiter, Thomas Gruber, Christina Lutz-Nicoladoni, Nikolaus Thuille, Friedrich Fresser, Verena Labi, Natalia Schiefermeier, Marei Warnecke, Lukas Huber, Andreas Villunger, Gregor Eichele, Sandra Kaminski, Gottfried Baier

Immunity, vol. 29(2), 2008 Jul 15, pp. 205-216

Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?

V Labi, F Grespi, F Baumgartner, A Villunger

Cell Death & Differentiation, vol. 15(6), 2008 May 1, pp. 977-987

Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates γ irradiation–induced thymic lymphoma development

Verena Labi, Miriam Erlacher, Stephan Kiessling, Claudia Manzl, Anna Frenzel, Lorraine O'Reilly, Andreas Strasser, Andreas Villunger

Journal of Experimental Medicine, vol. 205(3), 2008 Feb 17, pp. 641-655

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

Miriam Erlacher, Verena Labi, Claudia Manzl, Günther Böck, Alexandar Tzankov, Georg Häcker, Ewa Michalak, Andreas Strasser, Andreas Villunger

Journal of Experimental Medicine, vol. 203(13), 2006 Nov 25, pp. 2939-2951

BH3-only proteins in cell death initiation, malignant disease and anticancer therapy.

V Labi, M Erlacher, S Kiessling, A Villunger

Cell Death & Differentiation, vol. 13(8), 2006 Jul 1, pp. 1325-1338

The NF-κB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells

Anette Bauer, Andreas Villunger, Verena Labi, Silke F. Fischer, Andreas Strasser, Hermann Wagner, Roland M. Schmid, Georg Häcker

Proceedings of the National Academy of Sciences of the United States of America, vol. 103(29), 2006 Jun 18, pp. 10979-10984

BH3-only proteins Puma and Bim are rate-limiting for γ-radiation– and glucocorticoid-induced apoptosis of lymphoid cells in vivo

Miriam Erlacher, Ewa M. Michalak, Priscilla N. Kelly, Verena Labi, Harald Niederegger, Leigh Coultas, Jerry M. Adams, Andreas Strasser, Andreas Villunger

Blood, vol. 106(13), 2005 Nov 15, pp. 4131-4138