EXPERIMENTAL IMMUNOLOGY

Pathologies of the immune system represent a major threat to healthy aging because of their abundance and limited therapeutic options.

In our group, we study molecular control mechanisms of cell fitness and fate decisions with a major focus on immune cells and their progenitors, hematopoietic stem and progenitor cells. Through genetic cell culture and mouse models we aim to understand normal hematopoiesis and lymphocyte development/function in comparison to pathological conditions such as leukemia, lymphoma, immunodeficiency and autoimmunity. The resulting mechanistic insights should aid in the prediction and prevention of disorders, and lead to novel therapeutic strategies for therapeutic intervention.

Publications

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat

Verena Labi, Siying Peng, Filippos Klironomos, Mathias Munschauer, Nicolai Kastelic, Tirtha Chakraborty, Katia Schoeler, Emmanuel Derudder, Manuela Martella, Guido Mastrobuoni, Luis R. Hernandez-Miranda, Ines Lahmann, Christine Kocks, Carmen Birchmeier, Stefan Kempa, Leticia Quintanilla-Martinez de Fend, Markus Landthaler, Nikolaus Rajewsky, Klaus Rajewsky

Genes & Development, vol. 33, 2019 Nov 1, pp. 1673-1687

Addiction of B Cell Lymphomas to microRNA-17-92 Is Mediated By a Single Target Gene

Katia Schoeler, Teresa Mittermeier, Andreas Villunger, Klaus Rajewsky, Verena Labi

Blood, vol. 134, 2019 Oct 13, pp. 1258-1258

Transient apoptosis inhibition in donor stem cells improves hematopoietic stem cell transplantation.

Matthias Kollek, Gesina Voigt, Christian Molnar, Fabronia Murad, Daniela Bertele, Christopher Felix Krombholz, Sheila Bohler, Verena Labi, Stefan Schiller, Mirjam Kunze, Stephan Geley, Charlotte M. Niemeyer, Ana Garcia-Saez, Miriam Erlacher

Journal of Experimental Medicine, vol. 214(10), 2017 Sep 2, pp. 2967-2983

Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells

Emmanuel Derudder, Sebastian Herzog, Verena Labi, Tomoharu Yasuda, Karl Köchert, Martin Janz, Andreas Villunger, Marc Schmidt-Supprian, Klaus Rajewsky

Proceedings of the National Academy of Sciences of the United States of America, vol. 113(18), 2016 Apr 3, pp. 5065-5070

Tissue-specific DNA demethylation is required for proper B-cell differentiation and function.

Shari Orlanski, Verena Labi, Yitzhak Reizel, Adam Spiro, Michal Lichtenstein, Rena Levin-Klein, Sergei B. Koralov, Yael Skversky, Klaus Rajewsky, Howard Cedar, Yehudit Bergman

Proceedings of the National Academy of Sciences of the United States of America, vol. 113(18), 2016 Apr 3, pp. 5018-5023

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Projects

APOPTOSIS AS BARRIER TO AUTOIMMUNITY AND CANCER

The identification of the pro-apoptotic Bcl2-protein Bmf as specific regulator of B cell fitness and mediator of therapy-induced cell death (HDACi, glucocorticoids). Building on these results we discovered that Bmf and its relative Bim synergize in pro...